(R)-2-Amino-3-methylselanyl propionic acid
3-(Methylseleno)-L-alanine
CAS: 26046-90-2
Molecular Formula: C4H9NO2Se
(R)-2-Amino-3-methylselanyl propionic acid - Names and Identifiers
(R)-2-Amino-3-methylselanyl propionic acid - Physico-chemical Properties
| Molecular Formula | C4H9NO2Se |
| Molar Mass | 182.08 |
| Melting Point | 177 °C(dec.) |
| Boling Point | 314.1±37.0 °C(Predicted) |
| Flash Point | 152.155°C |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | White to slightly yellow powder |
| Color | White to slightly yellow |
| pKa | 2.17±0.10(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,2-8°C |
| MDL | MFCD00800565 |
(R)-2-Amino-3-methylselanyl propionic acid - Risk and Safety
| Risk Codes | R23/25 - Toxic by inhalation and if swallowed. R33 - Danger of cumulative effects R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | S20/21 - S28 - After contact with skin, wash immediately with plenty of soap-suds. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S60 - This material and its container must be disposed of as hazardous waste. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S28A - |
| UN IDs | UN 3283 6.1/PG 2 |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10-23 |
| HS Code | 29319090 |
(R)-2-Amino-3-methylselanyl propionic acid - Reference Information
| Application | 3-(methylselenyl)-L-alanine is also called L-selenomethylenocysteine, commonly used as selenium nutrition fortifier. It is the selenium methylated derivative of the 2 1st essential amino acid-L-selenocysteine. It is widely found in plants such as astragalus, garlic, onion and broccoli and selenium-rich yeast. It has a clear chemical structure, Low toxicity, high bioavailability, and good selenium supplementation effect. It not only has a preventive effect on a variety of tumors (such as breast cancer, prostate cancer, liver cancer, etc.), but also has an auxiliary effect on cancer treatment, it has broad application prospects. In 2002, selenium-methylselenocysteine was recognized by the US FDA as the latest generation of selenium-derived dietary supplements; in 2009, 3-(methylselenyl)-L-alanine was approved by the Ministry of Health of my country As a new nutritional fortifier (Announcement No. 11 of 2009 of New Food Additives). |
| Use | 2-amino-3-methylselenopropionic acid is an inhibitor of DMBA-induced breast tumors. |
| biological activity | Se-Methylselenocysteine, precursor of methyl selenium, has strong cancer chemoprevention activity and antioxidant activity. Se-Methylselenocysteine have oral bioactivity and can induce apoptosis (apoptosis). |
| Cell Line: | SKOV-3 cells SKOV-3 cells |
| Concentration: | 100, 200, 400 μM 100, 200, 400 μM |
| Incubation Time: | 3 days 3 days |
| Result: | Resulted in a markedly increased accumulation of Sub-G1 phase, which occurred in both SeMSC concentration and culture time-dependent. Resulted in a decrease in the expression of the 32 kDa form of procaspase-3. |
| Animal Model: | Female athymic nude mice (bearing human A253 and FaDu squamous cell carcinoma xenografts) |
| Dosage: | 0.2 mg/mouse |
| Administration: | p.o.; daily for 14 days (7 days before and 7 days after Cyclophosphamide or CDDP in a total of 14 days) |
Last Update：2024-04-09 02:00:07
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